Over a decade ago, O'Deorain made waves when she published a controversial paper detailing a methodology for creating custom genetic programs that could alter DNA at a cellular level. It seemed like a promising step toward overcoming diseases and disorders and maximizing human potential. Dissent among her peers soon followed. Many considered her work to be dangerous because of its perceived ethical shortfalls, and O'Deorain was even accused of having the same unchecked desire for scientific advancement that some believed had caused the Omnic Crisis. In addition, other geneticists were unable to reproduce the results of Moira's research, which further called her discoveries into question. Instead of kickstarting her career, her paper seriously damaged her reputation. Overwatch was among those who condemned her research, and in O'Deorain's own words, tried to silence her.
She received a lifeline in an offer from an unlikely source: Overwatch's covert ops division, Blackwatch. She was personally recruited by Blackwatch's commander, Gabriel Reyes, who wanted someone who could help advise him on matters pertaining to genetics. She continued her work in the shadows while developing new weapons and technologies for the organization. Freed from her shackles, her genetic research greatly accelerated. She had interactions with Blackwatch members Jesse McCree and Genji Shimada, all of whom had their likes and dislikes pertaining to each other. Among her experiments was one done Reyes himself. Her experiments on Reyes gave him super-human abilities, causing his cells to regenerate and decay at a hyper-accelerated rate. Her employment was a closely kept secret, until it was uncovered during inquiries following the Venice incident. Many high-ranking Overwatch officials disavowed all knowledge of her affiliation with them.
After Overwatch was disbanded, O'Deorain was forced to turn to unconventional sources of funding. This time, she was invited to join the scientific collective that had founded the city of Oasis, and was selected to be their Minister of Genetics. Yet some whispered that the shadowy Talon organization had already been supporting her for years, aiding her experiments in exchange for utilizing the results for their own purposes. By the time of Doomfist's return to Talon (or after his return), Moira apparently had a seat on Talon's inner council. O'Deorain's goals of pushing forward human evolution meshed well with Talon's, and she found a patron for her research in Doomfist.